COMPLETE Guide For Chemotherapy Effects and It's Treatment

Combination Chemotherapy Drugs

Cancer is a deadly disease for which a variety of treatments are available. One of the very important cures of cancer is chemotherapy. Chemotherapy originated in 1940 as chemical weapon agent nitrogen mustard was analyzed with its applications. The combination chemotherapy was evolved as a result of developments that the field of cure for cancer faced. The process of combination chemotherapy is very sophisticated, yet, it includes all the drawbacks and principles of the original chemotherapies.

Right after the World War II, the medicinal societies across the world strengthened their backs to fight against the deadly disease of cancer. United State of America played a pivotal role in searching for proper cure of the gruesome cancer disease that used to lead millions of deaths every year. These efforts paved ways for the evolution of the practice of combination chemotherapy.

In 1965, Emil Frei, James Holland and Emil Freireich brought a new theory and a new proposal. The suggestion they made was pretty simple as it stated that antibiotic treatment for cancer should be performed before the process of chemotherapy may be introduced to a cancer patient. The idea was to use a combination of various medicines to be applied before actually administrating the proper process of chemotherapy and that leaded to the concept and term of combination chemotherapy.

The originators of the idea of combination chemotherapy also suggested the probabilities of development of resistance in the cancer affected cells in human body against the curing action of chemotherapy. Thus, by using a combination of medicines, the physicians and surgeons will find better way to treat cancer patient. They tried to exemplify their theoretical idea by working with four different combined drugs that was termed as POMP regimen for the children who are suffering with acute diseases such as ALL (full form is acute lymphoblastic leukaemia. The result was amazing success as notable reductions of cancerous symptoms were noticed in the suffering patients for longer periods. The Medical Research Council of United Kingdom further worked to develop the original set of POMP regimen for cancer patients. After that only the deadly disorder known as ALL started to be understood as an easily curable disease.

As the new effective drugs were also invented, the premature success of combination chemotherapy to fight against cancer raised hopes of the probabilities to find out successful cures for all forms of the disease of cancer. All these highly raised hopes caused an overdrive in the pharmaceutical industry to invent, develop and produce the medicines in mass. The phenomenal drug overdrive provided a way to accurately apply previously dangerous doses of medicines for combination chemotherapy. In addition, in the same period, invention of bone marrow transplantation provided further relief for the cancer physicians and patients. Yet, the efficiency of bone marrow transplantation therapy was highly restricted with Hodgkin’s disease.
Research of the likes of Vincent T. DeVita and George Canellos proved that a chemical element combination known as MOPP regimen can be used to cure Hodgkin’s and non-Hodgkin cases of lymphoma.